Behind the data with Dan Knights and Joe Petrosino: Live discussion and Q&A
Join the next Diversigen webinar where leading pioneers in the microbiome industry, Dr. Dan Knights and Dr. Joe Petrosino, will discuss best practices for microbiome analysis, including longitudinal studies with shotgun metagenomics and real-use cases for WGS and 16S.
Dan Knights, Ph.D.
Senior Scientific Advisor at Diversigen, former CEO and founder of CoreBiome
Joseph F. Petrosino, Ph.D.Date: August 12, 2020
Senior Advisor at Diversigen
Time : 11:00 am ET
- Novel and actionable functional insights in microbiome research
- New breakthrough technology for at-home collection of human fecal samples for metabolomics
- Real-world case studies of metabolomics in clinical microbiome research
- Best practices in experimental design and computation analysis,
- Overcoming informatics interpretation challenges,
- New algorithms and software tools that enable new types of biomarker discovery in microbiome data, and
- The application of these tools to clinically relevant human and primate studies.
DNA Genotek's webinar program allows you to find out about various aspects of sample collection and its applications from the comfort of your own desk. Each 60-minute DNA Genotek webinar features an educational discussion, case studies, and a Q&A session.
Viral metagenomics and the use of standards: from biology to clinical applications Hosted by ATCC
Tasha M. Santiago-Rodriguez Ph. D. | Bioinformatician at Diversigen, Inc.
This webinar presents the implications of viruses membership and function within the human microbiome, and how the advent of metagenomics on these communities will continue to expand with the application of new sequencing technologies and analysis tools. This session highlights how this information is readily translating into clinical applications; the rapid sequence identification of pathogenic viruses and phage therapy, along with the implementation of viral standards and controls.
Metabolomics and the Microbiome Revolution: Critical Innovations to Unlock Gut Microbial Function in Human Health
Héloïse Breton, Ph.D. | Product Manager, Microbiome, DNA Genotek
Lisa Freinkman, Ph.D. | Staff Scientist, Metabolon
Suchitra Hourigan, MD | Vice Chair of Research, Inova Children’s Hospital
Thomas Schmidt, Ph.D | Professor, University of Michigan
In this webinar, we will explore how metabolomics enables a critical understanding of gut microbiome function in vivo as well as how recent technical innovations help overcome cold-chain requirements and other challenges related to collection, storage, and transportation of human fecal metabolomic samples. Join us for this dynamic panel discussion where our speakers will share their experiences related to:
Overcoming the challenges of sample collection in the time of COVID-19: Safe sampling for SARS-CoV-2
Rafal Iwasiow | Vice President, Innovation and Technology, DNA Genotek
Scott Rabuka | Senior Director, Molecular Products, DNA Genotek
Bernadette M. Mandes Wildemore, MD | Molecular Pathologist and Chief Medical Officer P23 Labs, LLC
As our industry faces new and unpredicted challenges, the importance of discussing solutions for sample collection in the time of COVID-19, increases. In this session, experts from DNA Genotek presented how safe, at-home sample collection is aiding in the work against SARS-CoV-2. P23 Labs also outlined data from their validation studies on their SARS-CoV-2 assay, which recently received Emergency Use Authorization by the Food and Drug Administration for clinical testing.
De-risking Microbiome Research and Clinical Discoveries: Robust At-Home Methods for Sample Collection, Storage and Transport
Jean Macklaim, Ph.D | Bioinformatician, DNA Genotek
Christina Fragel, MS | Bioinformatician, DNA Genotek
Learn the implications of unwanted variation for downstream analysis and how to generate more stable and representative sample results. Discover how the OMNIgene•GUT collection device combined with high-quality sequencing and analysis provided by Diversigen’s BoosterShot shallow shotgun approach, can help generate more stable and reproducible results, and provide opportunities for home collection while mitigating the need for cold-chain transfer.
Leveraging Diversigen’s bioinformatics platforms for CAZyme characterization and discovery
Eric Smith, PhD | Bioinformatician, Diversigen
Presented by Eric Smith, Ph.D., Bioinformatician at Diversigen, this webinar explains how carbohydrates are key metabolites that shape and fuel the microbiome. Carbohydrate active enzymes (CAZymes) are the repertoire of genes necessary for their metabolism.
Learn how Prescient Metabiomics is implementing CAZyme characterization in their clinical studies and how to apply their approaches to your pipeline.
Standardization in microbiome measurements: Considerations from sampling to analysis
Microbiomes are complex systems, and gaining insights often requires analysis of large data sets from large numbers of samples. Microbiome measurements are subject to the introduction of error and bias at many steps and robust analysis requires overcoming challenges due to variability introduced during collection, extraction, and downstream applications. The lack of precise methods, standardized procedures, reference materials and quality control metrics for analyzing microbiomes limits reproducibility/comparability among studies (at best), and can lead to discordant data interpretation and false inferences (at worst); ultimately, limiting progress in identifying specific disease modulatory mechanisms in microbiome research. The microbiome field can only reach its translational potential when hypotheses are rigorously tested with optimized and reproducible methods.
In this webinar, the experts at CoreBiome and DNA Genotek cover a range of topics on microbiome standardization, including:
High Quality Libraries for Human WGS with Direct Saliva Input
Experts in DNA sequencing and DNA from saliva talk about what's trending in whole genome sequencing (WGS). Joshua Burgess, Manager of Research and Development at Illumina, and Rafal Iwasiow, Vice President of Research and Development at DNA Genotek, will discuss why human genomic research is moving towards WGS and what this means for research study design and planning. They will also look at the viability of saliva as a DNA sample source, as compared to blood, for whole genome sequencing using Illumina's Nextera DNA Flex to produce high quality libraries for WGS.
The Key to Eliminating Bias in Genetic Studies Could be in Our Spit
In recent years, saliva has emerged as an increasingly useful source of DNA, making its mark in epigenetic studies of psychiatric diseases, diagnosing HIV, and in the rise of direct-to-consumer genetic testing. The ease of which a saliva sample can be collected and its ability to be stored at room temperature without DNA degradation has allowed for the increased inclusion of children and under-represented, non-European populations in genetic studies. But does the quality and integrity of DNA from saliva match up to the standard? A panel of experts including: Dr. Joan O’Brien, chair of the University of Pennsylvania’s Department of Ophthalmology and Dr. Alicia Smith, Associate Professor and Vice Chair for Research, Gynecology and Obstetrics at Emory University School of Medicine, come together to discuss the benefits and drawbacks on the use of saliva DNA in genetic studies and how it’s currently being used to diminish biases in our databases and uncovering the role of epigenetics in psychiatric disorders.
Microbiome-centric human health: a call for systems biology
Research to date has implicated microbial activity in autoimmune disease, cancer, and the obesity epidemic. As a major source of variability across people, understanding and altering an individual's microbiome is both a challenge and novel avenue for personalized medicine and nutrition. Dr. Eran Segal of the Weizmann Institute of Science, Israel shares his research using OMNIgene·GUT, summarizes the state of the science, and discuss the next steps in developing personalized microbiome-based therapies.
Curating massive amounts of biological material and phenotypic data for robust & reproducible microbiome discovery
Over 100 microbiome-centred therapeutics programs are currently moving through clinical development. Venture and industry investment in the field has topped $1B in the past 5 years. Over that same period, academic research funding has seen compound growth exceeding 20% per year. Of these enormous inputs, what proportion has generated real insight and how much of this output is noise? This short talk will highlight solutions DNA Genotek has deployed for its customers conducting population-scale research and delivering Direct-to-Consumer insights. We make curating massive amounts of biological material and phenotypic information scalable and reproducible.
Integrating the Microbiome into Your Research
Watch this presentation highlighting how you can effectively integrate the microbiome into any genetic research project.
Overcoming Challenges in DNA Sample Acquisition for Cancer Research
Obtaining high quality genomic DNA is critical for studies that aim to evaluate the role of genetic factors in cancer. However, cancer research studies often require very large numbers of samples from a dispersed population and non-invasive methods for DNA collection. Saliva samples, which are painless for the donor and relatively easily collected, are quickly becoming the preferred choice. Cancer research groups around the world are now focusing on the potential of this common bodily fluid for detecting the genetic link to the disease and studying genes.