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Description of Services

Affiliated Genetics Inc. (AGI) was founded in April 1994 in order to provide DNA-based diagnostic testing focusing exclusively on human identity. AGI is committed to provide outstanding customer service with a highly trained staff of scientists, technicians and customer service representatives. We have an ongoing research effort to develop new ways to enhance DNA identity testing and provide the services that our customers need. The laboratory meets and exceeds all relevant standards for paternity and forensics laboratories and is one of less than 40 laboratories world-wide accredited by the American Association of Blood Banks (AABB) for relationship testing. Affiliated Genetics is CLIA, CAP and AABB accredited. We provide a wide range of clinical testing and laboratory services to researchers, law enforcement and corporate clients.

Description of Services

AGRF provides DNA and RNA extraction services for a wide range of starting materials including the Oragene Saliva self-collection kits. The appropriate extraction system is selected, or customised, according to the requirements of the project. Downstream genomic services following extraction are also available from AGRF and include: genotyping, Sanger sequencing, next-generation sequencing (GS FLX and GA II), gene expression, SNP analysis, methylation analysis and bioinformatics.

Lab Location and Locations served:

AGRF Adelaide
Plant Genomics Centre
Hartley Grove
Urrbrae
Australia
SA5064

Description of Services

• Genome characterization and sequencing
• Genotyping assay development and validation
• Gene expression profiling and validation
• Drug efficacy and safety-related analysis
• Biologics evaluation and safety testing
• Data management, analysis and interpretation
• Sample management and biobanking
• Scientific consulting

Description of Services

As your premier scientific partner, we provide a comprehensive list of genomic solutions to meet your research needs. Our facilities feature Sanger and next-generation sequencing technologies, providing the highest throughput sequencing capacity in the world. Powered by 137 Illumina HiSeq 2000 instruments and 27 Applied Biosystems SOLiD 4 Systems, we provide high-quality sequencing results with industry-leading turnaround time. Our high-performance supercomputing facilities (with a total of 102 Tflops, 20 TB of memory, and 10 PG of storage) and bioinformatics center (with 1000 professionals) provide the hardware and software tools and analysis capabilities to support genomics research, eliminating the next-generation sequencing analysis and data processing bottleneck for our customers.

Applications: With the diverse analytical technologies now available, we can focus the full spectrum of multi-omics methods on the important research questions that impact agriculture and human health. BGI is deeply committed to supporting multi-omics research by providing our deep sequencing and analytical resources to our collaborators and clients.

Human Disease Research: See how we have built upon human genome research using next-generation sequencing technologies to study human health and disease in areas such as cancer, Mendelian disease, genetic and epigenetic analysis, and pathway research.

Agriculture: Learn about our application of next-generation sequencing to plant and animal research where we have sequenced the whole genome of numerous plants and animals and identified markers and functional genes that contribute to the study of molecular breeding, agriculture production, and conservation.

Drug R&D: Explore the many next-generation and related technologies offered by BGI. See how they can accelerate discovery and selection of new drug targets and candidate compounds, as well as provide important data throughout the drug-development life cycle.

Description of Services

BioRep S.r.l. is an independent "SERVICE PROVIDER" organization offering biorepository services to public and private research institutes, to the highest standards of quality and safety. In addition to the storage service, BioRep provides Cell Biology, Molecular Biology, Microbiology, Media preparation services developed in ISO9001/2000 certified laboratories (i.e. establishment, maintenance and distribution of cell line cultures as well as DNA derived from these cultures; nucleic acids isolation and distribution, genotyping, sequencing; mycoplasma detection in animal cell cultures; etc).

Applications

• DNA extractions from whole blood (performed manually using the salting-out method).
• DNA extractions from saliva (performed manually using the protocol for 4.0 ml of Oragene®•DNA saliva).
• DNA quantification (and purity evaluation) performed by absorbance using the Nanodrop 1000 spectrophotometer.

Description of Services

DNA and RNA extractions, Realtime PCR analysis, SNP analysis using Sequenoms iPLEX system, expression analysis using the Taqman system. Manual extraction of RNA and DNA. We utilize our proprietary DNA extraction reagents, DNAQuick for DNA extraction from most of the sources. We also utilize Qiagen column protocols for some sample types. For RNA extractions we typically use Tri-reagent method and some times utilize Qiagen column based protocols. We have Standard Operating Protocols (SOPs) for all the different applications.

Description of Services

Genomics project consultation and design, Genomic DNA preparation (including OrageneDNA), DNA Sequencing, including capillary Sanger, Solexa/Illumina, Roche/454 and ABI SOLiD next-generation sequencing, Oligonucleotide Synthesis, Microarray Analysis (Affymetrix, Agilent, Illumina DNA arrays, all using OrageneDNA; also expression arrays), Genotyping (MegAllele, Taqman, SNaPshot, microsatellite), Cytogenomics (karyotyping, FISH mapping, SKY, transgene mapping, breakpoint analysis), Genomic and cDNA library clone distribution and probe labeling, Statistical Consultation and Analysis, Biobanking and Cell Culture, Bioinformatics.

Lab Location and Locations served:

TCAG provides services to researchers in Ontario, the rest of Canada and worldwide.

Description of Services

CIGMR offers study design, sample collection, processing and storage using state of the art equipment and developed and tested techniques and processes backed by a high commitment to quality through ISO 9001/2000 accreditation.

CIGMR also provides expertise in areas such as genetic study design and data analysis, ethics committee applications, and bioinformatics. Comprehensive high-throughput laboratory facilities including a range of genotyping platforms, DNA sequencing, DNA extraction and archiving, mutation screening, microarray transcriptomics, SNP discovery and HLA tissue typing. The Centre enters into both academic research collaborations and works with industry on a service basis.

Locations Serviced:

CIGMR, The University of Manchester, UK.

Description of Services

We are a fully integrated 'omics' service provider, specialising in complete genomics, proteomics and bioinformatics services. Our services include: sample preparation (extraction of DNA, RNA and protein), Affymetrix cartridge arrays (aCGH, DNA methylation, Exon expression, Gene expression, miRNA expression, Genotyping, DMET Plus, CytoScan HD), Affymetrix GeneTitan arrays (Gene expression profiling, Genome-wide analysis and genotyping applications, custom arrays), qRT-PCR (genotyping, qRT-PCR, TLDA, viral titres), Next Generation Sequencing (microbial genome sequencing, whole genome de novo sequencing, whole genome sequencing, whole exome sequencing, whole transcriptome sequencing).

Description of Services

Complete Genomics is a whole human genome sequencing company that has developed and commercialized an innovative DNA sequencing platform. The Complete Genomics Analysis Platform (CGA™ Platform) combines Complete Genomics' proprietary human genome sequencing technology with advanced informatics and data management software. Dedicated to whole human genome sequencing and analysis provided as a simple outsourced service, Complete Genomics provides researchers with highly accurate genomic data, assembled and annotated, ready for biological interpretation. And by optimizing our sequencing platform for human DNA, we have achieved industry-leading accuracy levels of 99.9998%. Our sequencing service provides researchers an ability to increase their understanding of the genetic mechanisms underlying drug responses and complex diseases in order to improve human healthcare.

Products Supported:

Oragene•DISCOVER, Oragene•DNA

Description of Services

CynerGene LLC is available to offer solutions to genomic service needs. Located in the Maryland biotech corridor outside Washington DC, we provide quality services for SNP genotyping, gene expression, DNA methylation and microarray assays. We are recently providing fine-mapping genotyping service using the industry leading BeadExpress platform from Illumina at low cost. This would be extremely ideal for running your samples for low plexing. Illumina's VeraCode technology leverages the power of digital holographic codes to provide a robust detection method for multiplex assays requiring high precision, accuracy, and speed. CynerGene is a GLP compliant laboratory dedicated to providing high quality, QC centric services for the scientific community at a cost effective price.

Locations Serviced:

Lab is located in Frederick, Maryland. Cynergene is capable of providing services worldwide.

Description of Services

Agricultural Genomics - DNA LandMarks provides DNA analysis to assist plant and animal breeders do their work more efficiently.

Validated for Performagene•LIVESTOCK.

Applications:

SNP marker discovery and development. Association mapping studies. Linkage mapping studies. Fingerprinting (parentage, traceability, etc). Marker-assisted selection. Marker-assisted backcrossing.

Locations Serviced or Lab locations:

Services available globally.

Description of Services

The mission of the DNA Bank and Tissue Repository at the CHG is to continue to provide genetic sample processing and storage that sets the national standard for such facilities.

Locations Serviced or Lab locations:

Durham, NC.

Description of Services

DNA & RNA extraction from blood, Oragene kits, stool and tissue. PBMC, plasma and serum isolation. Sample storage and biobanking. Taqman genotyping, Illumina genotyping and Next-Generation Sequencing.

Lab locations or locations where services are offered:

Services provided to researchers across Scotland, the rest of the UK and Europe.

Description of Services

Expression Analysis provides expression profiling and genotyping services using Affymetrix, Illumina, Luminex and Applied Biosystems' TaqMan® technologies. As the leading provider of microarray services in clinical trials, Expression Analysis offers solutions for challenging specimens, such as blood and FFPE tissues, as well as nucleic acid isolation and data analysis services. The company also performs diagnostic assays in its CLIA and GLP-compliant laboratory.

Lab location and locations served

The Expression Analysis facility is located in Durham, NC. Our services are provided worldwide to a variety of clients including most of the top 10 pharmaceutical companies.

Expression Analysis, Inc.
4324 South Alston Avenue, Suite 101
Durham, NC 27713

Description of Services

The Research Cell Bank (RCB) is a qualified, experienced laboratory that has been actively engaged in clinical research through B-lymphoblastoid cell (B-LCL) transformation and maintenance, DNA extraction, and inventory control for more than 30 years. The RCB is engaged in contractual, fee-for-service work for external entities requiring a large laboratory with expertise in the processing of blood and tissue samples, production of B-LCL, DNA extraction, cryopreservation, and maintenance of a large-scale frozen repository.

Applications:

Purification of DNA using Oragene is only done manually utilizing a modified salting out protocol with 5 Prime reagents. Isolated genomic DNA is rehydrated in T/E buffer at room temperature. The concentration of DNA is determined by a Spectramax 384 Plus spectrophotometer optical density (OD) measurement at 260 nm; the relative purity by OD 260/280 ratio.

Lab locations or locations where services are offered:

Fred Hutchinson Cancer Research Center,
Research Cell Bank
1100 Fairview Ave N. D2-346
Seattle, WA 98109

Description of Services

Tepnel Pharmaceutical Services

Tepnel Pharmaceutical Services offers an established and comprehensive range of analytical services to the Pharmaceutical, Biotechnology and Academic/Clinical Research sectors.

Contract services include: DNA & RNA extraction; sample quantification & normalisation; whole genome amplification; singleplex & array-based genotyping, expression analysis and sample archiving.

Lab Location and Locations served:

Gen-Probe Life Sciences Ltd.
Heron House, Oaks Business Park
Crewe Road, Wythenshawe
Manchester
M23 9HZ

Gen-Probe Life Sciences Ltd.
Appleton Place
Appleton Parkway
Livingston
West Lothian
EH54 7EZ

Description of Services

Genetic Repositories Australia (GRA) is a national genetic repository for DNA and cell lines derived from appropriately consented disease-specific and population-based studies. GRA has been supported by an NHMRC Enabling Facility Grant and is based at the Prince of Wales Medical Research Institute (POWMRI).

GRA provides researchers with a central facility for the processing, long-term secure storage and distribution of human genetic samples (DNA and cell lines). This includes the production and provision of immortalised lymphoblast cell lines and DNA samples.

GRA service requests currently cover cell line establishment and DNA extraction from human whole blood, saliva (Oragene), cell lysates and cultured cells.

GRA Platforms:
QIAGEN Autopure LS,
LCL immortalisation

Lab Location and Locations served:

Prince of Wales Medical Research Institute
Barker Street
Randwick
Sydney, Australia
NSW, 2031

Description of Services

Affiliated Genetics Inc. (AGI) was founded in April 1994 in order to provide DNA-based diagnostic testing focusing exclusively on human identity. AGI is committed to provide outstanding customer service with a highly trained staff of scientists, technicians and customer service representatives. We have an ongoing research effort to develop new ways to enhance DNA identity testing and provide the services that our customers need. The laboratory meets and exceeds all relevant standards for paternity and forensics laboratories and is one of less than 40 laboratories world-wide accredited by the American Association of Blood Banks (AABB) for relationship testing. Affiliated Genetics is CLIA, CAP and AABB accredited. We provide a wide range of clinical testing and laboratory services to researchers, law enforcement and corporate clients.

Description of Services

The Georgia Genomics Facility (GGF) fosters excellence in investigator-led genomics studies. GGF provides genomic services through access to cutting edge technologies. Our services include DNA purification for a wide range of starting materials including the Oragene Saliva self-collection kits, genotyping, Sanger sequencing using the ABI 3730xl instrument, Next-Generation sequencing on the Illumina MiSeq and NextSeq platforms, as well as BioNano whole-genome mapping.

Lab locations or locations where services are offered:

University of Georgia, Georgia Genomics Facility (GGF)
110 Riverbend Road, Room 161
Athens, Georgia, 30602

Description of Services

In the field of DNA typing, Dr. Van Haeringen Laboratorium b.v. (VHL) has obtained a worldwide reputation over the last 25 years by quality, service and know-how. At the moment VHL offers over 1,000 routine tests for animals, plants and micro-organisms. In collaboration with clients, VHL performs many different projects in various fields. VHL collaborates with clients from different areas of expertise, such as agriculture including veterinarian diagnostics, the pharmaceutical industry, feed & food technology, basic research and organizations related to accompanying animals.

As a DNA Service Laboratory VHL is experienced on several DNA techniques such as Genotyping of SNPs and InDels, MCPC, Sequencing, realtime PCR for pathogen detection, microsatellite analysis, etc. As a technology leader, VHL is used to implement new techniques fast and reliable.

The availability and possibilities of DNA and RNA Technologies has enabled Genetic Services of an entirely new level. Within our scopes, genetic testing is based on a selection of High Throughput platforms, enabling optimal quality and flexibility for a wide spectrum of applications:

• Genotyping Services for SNPs / InDel
• Microsatellite (STR) Genotyping Services
• DNA extraction services
• Bio Banking
• Routine Mutation Analysis
• Real Time Pathogen Detection

Description of Services

• DNA Extraction
• SNP genotyping (From single SNP to genome wide scan)
  • Platforms: TaqMan®, Fluidigm, Illumina®
  • Custom SNP genotyping
  • LOH SNP analysis
  • CNV/CGH studies
  • Pharmacogenetic studies
  • DNA methylation analysis
• New generation Sequencing Genome Analyzer II
  • SNP detection and Discovery
  • Sequence enrichment with Agilent SureSelect kits
  • Long Inserts Rearrangements Analysis
  • CHIP Seq, miRNA Seq, DGE
  • De novo Sequencing

Lab Location and Locations served:

5 rue Henri Desbruères
Genopole Campus 1
Genavenir 8
91030
Evry, France

Description of Services

Core and collaborative facility specializing in DNA extraction services, low and mid-throughput genotyping.

Lab locations or locations where services are offered:

Johns Hopkins, Bayview
JHAAC, Rm 3A2
5501 Hopkins Bayview Circle
Baltimore, MD 21224

Description of Services

Masmec Biomed designs and provides devices for the medical and biotech sectors. We have a solid background in mechatronic, robotic and signal processing technologies, as we are a division of MASMEC S.p.A, a leader in this field. Our products are developed by a team of specialists combining different skills and expertise in computer science, electronics, biomedicine and biology.

We specialize in liquid handling for automatic DNA and RNA extraction and plate preparation for research and analysis labs. We offer a family of biotech workstations, named OMNIA, fitting many protocols in molecular biology, genomics, proteomics and pharmacology. OMNIA workstations support human, animal and plant DNA and RNA extraction, amplification setup, plate preparation, post-PCR purification and biobanking for research and analysis, enabling fast, accurate and very flexible processing. OMNIA Prima is an automated system for extracting DNA and RNA from blood, saliva or other biological fluid samples, tissues and plant samples(leaves, roots). This workstation is based on magnetic bead technology and it is able to process up to 24 samples at a time in less than 100 minutes. It is possible to use one of the recommended and validated extraction kits, whose automatic protocol is already available, or to test and employ other magnetic bead-based kits or specific protocols, counting on customized management for each lab.

Technical support is guaranteed during the whole life cycle of any MASMEC Biomed product. After first extraction tests with our instrument and your kits, we can provide genomic services for DNA and RNA extraction for your customers starting from your Oragene kit. At the same time we are looking for international distributors of our instruments.

Description of Services

Maxxam provides a comprehensive menu of species and breed-specific tests that help breed associations broaden the services that they supply to their members. We work with industry leaders to apply genetic technologies to address issues of breed traceability and product improvement. Maxxam provides services that include genetic identity testing; DNA parentage confirmation; diagnostic detection of specific genetic diseases and traits of interest; high-quality and yield DNA purifications; and custom projects for clients.

Applications:

Maxxam employs a suite of molecular markers for genetic identity, DNA parentage and detection of specific genetic diseases and traits of interest.

Lab locations or locations where services are offered:

Maxxam - Animal DNA Laboratory
335 Laird Road, Unit 2
Guelph, Ontario N1H 6J3

Description of Services

OGT was founded in 1995 by the pioneer of microarray technologies, Professor Sir Edwin Southern. The key focus areas of OGT are high throughput microarray and biomarker discovery. OGT also has an extensive range of cytogenetic products and services, including high resolution oligonucleotide arrays, labeling kits and our analysis software, Interpret.

Applications

In our high throughput laboratories we can process arrays for aCGH and CNV studies, ChIP and methylation samples and also gene expression and miRNA profiling. The sample handling and labeling steps are fully automated. Currently most of our projects are run using the Agilent platform.

Description of Services

PreventionGenetics provides Clinical DNA Testing, DNA Banking and Research Genomics services for the medical and research communities both nationally and internationally.

Applications:

Our CLIA-accredited lab offers DNA sequencing tests and a gene-centric array CGH test for over 400 human genes. We focus especially on tests for neuromuscular, developmental, ciliopathy, blood, infertility, skeletal, metabolic, cancer, heart, kidney, and vision disorders. We provide fast turnaround times, outstanding personalized service, clear and complete test reports, and prices that are among the very lowest in the industry. Our menu of tests is continually expanding.

Lab Location and Locations served:

PreventionGenetics
3700 Downwind Drive
Marshfield, WI 54449

Description of Services

ProntoLab, the molecular services division of Pronto Diagnostics, provides clinical molecular diagnostics services as well as research services which include:

• Oncogenetic testing - BRCA, FAP, HNPCC - Full sequencing/Point mutations/Deletions/Duplications
• Pharmacogenetic testing - 5FU, Clopidogrel, Irinotecan, Tamoxifen, Warfarin
• Other tests - FMF, TRAPS, THROMBOPHILIADNA Sequencing Fragment Analysis Deletions/Duplications Analysis (MLPA)

Lab location and locations served:

ProntoLab
19A Habarzel St.
Ramat Hachayal, Tel-Aviv 69710, Israel

Description of Services

RIKEN GENESIS has been established as a RIKEN venture company to take over the technologies developed by RIKEN. We offer cutting-edge genotyping services using Illumina technology to a wide range of research institutions and corporations, both within Japan and overseas. We performs in CAP (College of American Pathologists) & GLP-compliant laboratory. Furthermore, the next generation sequencing and bioinformatics services are available.

Applications:

• DNA Extraction Services (Validated for Oragne•DNA)
• Next Generation Sequencing Services
• Genotyping Services
• Bioinformatics Services
• DNA Banking Services

Lab locations or locations where services are offered:

Riken Yokohama Institute
East Research Building 3F
1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama-shi, Kanagawa,
230-0045 JAPAN

Description of Services

Salimetrics specializes in saliva research and has expanded to offer genetic testing services, customer support and technical advice. Our saliva DNA specialists are able to customize protocols to provide you with successful genotyping projects and meaningful results.

• DNA Extraction
• Single Nucleotide Polymorphism (SNP) Genotyping
• Variable Number Tandem Repeat (VNTR) Analysis
• Short Tandem Repeat (STR) Analysis

Salimetrics provides innovative salivary assay tools, testing services and analyses to researchers studying genetic and hormone markers affecting health, behavior and development.

Description of Services

Source BioScience AUTOGEN™ & Geneservice™ is a contract research service provider and biological resource centre used by research companies and academic institutions worldwide. We are fully CPA, GLP/GCP accredited & most recently we have been awarded CSPro certification. With an archive of more than 16 million DNA samples, over 100,000 specialist and innovative products and a comprehensive portfolio of genomic services supported by the latest platforms and technologies, we are the only company that offers such a unique and wide ranging product and service collection.

Lab location and locations served:

Source BioScience offers genomic services and products worldwide. Our laboratories are based in Cambridge, Dublin, London, Nottingham and Oxford

Description of Services

StemCore Laboratories is a high-throughput genomics facility within the Ottawa Hospital Research Institute (OHRI). StemCore Laboratories is developing a world-class infrastructure for genomics, bioinformatics, and proteomics, and is capable of facilitating large-scale scientific research and biotechnology projects. Stemcore Laboratories seeks out projects that are challenging, cutting-edge, extend the boundaries of biological knowledge, and will positively impact the state of human health.

Applications:

Illumina Next Generation SequencingDNA SequencingAffymetrix GeneChip TechnologyCell SortingLab-on-a-Chip Bioanalysis.

Lab location and locations served:

StemCore Laboratories Address: 501 Smyth Road, Sprott Centre for StemCell Research, Room 5132 Critical Care Wing Ottawa, Ontario K1H 8L6

Description of Services

TATAA Biocenter is a commercial research provider that offers commissioned research and training within molecular diagnostics and gene expression analysis using real-time PCR and other molecular techniques to quantify nucleic acids. Our competence is based on knowledge and experience accumulated through years of research at leading European Universities. Our offer comprises the entire field of real-time PCR services including commissioned research, hands-on training, and custom design of real-time PCR assays.

Lab locations or locations where services are offered:

TATAA Biocenter, Gothenburg, Sweden

Description of Services

Sample Management: management of collections of large numbers of biological samples for the use in scientific investigation. We can manage all aspects of sample collection from initial processing (e.g. DNA extraction, plasma/serum separation), long term storage (-80C, -20C) and distribution of resultant samples to third party clients if required. We have expertise in the collection and management of associated clinical data via our website and collaboration management tool. All our laboratory procedures are fully audit trailed using our LIMS system and we are ISO9001:2000 accredited.

Lab Location and Locations served:

UDBN
Centre for Integrated Genomic Medical Research
Stopford Building
University of Manchester
Oxford road
Manchester
M13 9PT

Description of Services

Genomic DNA isolation, DNA quantification, DNA normalization, DNA Banking, Custom PCR Services, Genotyping, DNA sequencing (Sanger), Microsatellite and DNA fragment analysis, Next Generation Sequencing (454, Torrent, HiSeq), custom sample processing pipeline construction

Lab location and locations served:

University of Arizona Genetics Core
Keating BioResearch Building
Tucson, Arizona 85719

Description of Services

DNA Extraction
May contact other core facilities for downstream applications

Lab location and locations served:

UCSF Mission Bay Campus, Rock Hall 515

Description of Services

The Facility provides sample preparation, assay design, lab work, and initial data analysis for a variety of SNP genotyping platforms including custom TaqMan, Beckman SNPstream, and Illumina GoldenGate, as well as whole-genome genotyping by Illumina Infinium and Affymetrix GeneChip systems. Diagnostic testing with DNA or RNA-based assays are developed and performed for clinical research applications.

Locations Serviced or Lab locations:

Primarily service to the greater Philadelphia region; open to clients worldwide.

Description of Services

The Genomics and Proteomics Core Laboratories have extensive RNA/DNA extraction experience for dozens of tissue types including saliva, whole or frozen blood, tissue, cultured cells, buccal cells, and cell lines. GPCL also provides services in DNA sequencing, SNP genotyping and RNA analysis.

Please visit our web site for more information.
www.genetics.pitt.edu

Lab location and locations served:

University of Pittsburgh
Genomics & Proteomics Core Laboratories
3343 Forbes Avenue
Pittsburgh PA, 15260

Description of Services

Genomic Analysis (Paternity Test, Papillomavirus Genotypification, detection of KRAS, JAK-2 and Factor V mutation).

Lab location and locations served:

Vitagenesis, S.A. de C.V.
Boulevard Puerta del Sol #1005
Monterrey, Nuevo León, México, 64630